3-MEO-PCP Advanced Research On Chemical Intermediates 3-Methoxyphencyclidine 72242-03-6

3-MEO-PCP Advanced Research On Chemical Intermediates 3-Methoxyphencyclidine 72242-03-6

1. Quick Details

2. Definition

3-Methoxyphencyclidine (3-MeO-PCP) is a dissociative anesthetic drug that has been sold online as a designer drug. The compound was first synthesized in 1979 to investigate the structure-activity relationship of phencyclidine derivatives.

3-Methoxyphencyclidine (abbreviated as 3-MeO-PCP; also known as Methoxyphencyclidine) is a synthetic hallucinogenic dissociative of the arylcyclohexylamine class. Like its close analogs PCP, PCE and 3-MeO-PCE it is known for its potent anesthetic, hallucinogenic and stimulant effects.

The compound was first synthesized in 1979 to investigate the structure-activity relationship of phencyclidine (PCP) derivatives. The activity of 3-MeO-PCP in humans was not described until 1999 when a chemist using the pseudonym John Q. Beagle wrote that 3-MeO-PCP was qualitatively similar to PCP with comparable potency.

Today 3-MeO-PCP is used as a recreational drug and an entheogen, rarely sold on the streets and almost exclusively obtained as a grey area research chemical through the use of online vendors. Its routes of administration include vaporization and IM/IV injection along with the more traditional routes of administration such as oral or nasal administration.

3. Effect and History

The activity of 3-MeO-PCP in humans was not described until 1999 when a chemist using the pseudonym John Q. Beagle wrote that 3-MeO-PCP was qualitatively similar to PCP with comparable potency. 3-MeO-PCP binds to the NMDA receptor with higher affinity than PCP and has the highest affinity of the three isomeric anisyl-substitutions, followed by 2-MeO-PCP and 4-MeO-PCP.

Though 3-MeO-PCP is often described as having opioid or dopaminergic activity,[2] this supposition is contradicted by data showing 3-MeO-PCP to be a potent and selective ligand for the NMDA receptor without appreciable affinity for the µ-opioid receptor or dopamine transporter.[3][4] 3-MeO-PCP was preceded by the less potent dissociative 4-MeO-PCP and first became available as a research chemical in 2011.

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