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|Iupac Name:||1-pentyfluoro-1H-indole-3-carboxylic Acid 8-quinolinyl Ester||Formula:||C23H21FN2O2|
pharmaceuticals api intermediates,
intermediates in pharma
1400742-41-7 5F PB22 Research Chemical Stimulants For Chemical Research
|Means Of Transport:||Air||Package:||In Foil Bag Or Customized|
5F-PB-22 (5F-QUPIC or Quinolin-8-yl 1-pentyfluoro-1H-indole-3-8-carboxylate) is a designer drug which acts as a cannabinoid agonist.
The structure of 5F-PB-22 appears to have been designed with an understanding of structure-activity relationships within the indole class of cannabinoids.
5F-PB-22 acts as a full agonist with a binding affinity of 0.468nM at CB1 and 0.633nM at CB2 cannabinoid receptors.
Molecular weight: 384.470
Compound purity: > 99.7%
Related substance: Total Impurities(%) ≤ 0.3%
IUPAC:1-(cyclohexylmethyl)-1H-indole-3-carboxylic acid 8-quinolinyl ester
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PB-22 (QUPIC or 1-pentyl-1H-indole-3-carboxylic acid 8-quinolinyl ester) is a designer drug offered by online vendors as a cannabimimetic agent, and detected being sold in synthetic cannabis products in Japan in 2013.
The structure of PB-22 appears to use an understanding of structure-activity relationships within the indole class of cannabimimetics,[original research? although its design origins are unclear. PB-22 represents a structurally unique synthetic cannabinoid chemotype, since it contains an ester linker at the indole 3-position, rather than the precedented ketone of JWH-018 and its analogs, or the amide of APICA and its analogs.
PB-22 has an EC50 of 5.1 nM for human CB1 receptors, and 37 nM for human CB2 receptors. PB-22 produces bradycardia and hypothermia in rats at doses of 0.3–3 mg/kg, suggesting potent cannabinoid-like activity. The magnitude and duration of hypothermia induced in rats by PB-22 was notably greater than JWH-018, AM-2201, UR-144, XLR-11, APICA, or STS-135, with a reduction of body temperature still observable six hours after dosing. One clinical toxicology study found PB-22 to be the cause of seizures in a human and his dog.
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