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|Formula:||C15H21NO||Molecular Weight:||231.333 G/mol|
Reactive TH PVP Research Chemical Intermediates Pharmaceutical Purity 99.9%
|2||Full chemical name||RS)-1-Phenyl-2-(1-pyrrolidinyl)-1-pentanone|
|10||Formulation A powder solid|
|11||λmax 221, 315 nm|
|12||Shipping Wet ice in continental US; may vary elsewhere|
α-Pyrrolidinopentiophenone (also known as alpha-pyrrolidinovalerophenone, α-PVP, alpha-PVP, O-2387, β-keto-prolintane, Prolintanone, or Desmethyl Pyrovalerone) is a synthetic stimulant of the cathinone class developed in the 1960s that has been sold as a designer drug.
Colloquially it is sometimes called flakka or gravel. α-PVP is chemically related to pyrovalerone and is the ketone analog of prolintane.
α-PVP, like other psychostimulants, can cause hyperstimulation, paranoia, and hallucinations. α-PVP has been reported to be the cause, or a significant contributory cause of death in suicides and overdoses caused by combinations of drugs.
α-PVP has also been linked to at least one death where it was combined with pentedrone and caused heart failure.
α-PVP acts as a norepinephrine-dopamine reuptake inhibitor with IC50 values of 14.2 and 12.8 nM, respectively, similar to its methylenedioxy derivative MDPV.
α-PVP gives no reaction with the marquis reagent. It gives a grey/black reaction with the mecke reagent.
α-PVP may be quantified in blood, plasma or urine by liquid chromatography-mass spectrometry to confirm a diagnosis of poisoning in hospitalized patients or to provide evidence in a medicolegal death investigation. Blood or plasma α-PVP concentrations are expected to be in a range of 10–50 μg/L in persons using the drug recreationally, >100 μg/L in intoxicated patients and >300 μg/L in victims of acute overdosage.
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