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U48800 white powder Research Chemical Intermediates CAS No 82657-23-6

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U48800 white powder Research Chemical Intermediates CAS No 82657-23-6

China U48800 white powder Research Chemical Intermediates CAS No 82657-23-6 supplier

Large Image :  U48800 white powder Research Chemical Intermediates CAS No 82657-23-6

Product Details:

Place of Origin: China
Brand Name: DM
Certification: SGS
Model Number: 01

Payment & Shipping Terms:

Minimum Order Quantity: Negotiation
Price: Negotiation
Packaging Details: Aluminium foil bags and boxes; as your demand
Delivery Time: 1-2 days
Payment Terms: Western Union, MoneyGram,Bitocoin
Supply Ability: 500kg/month
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Detailed Product Description
Purity: 99% Color: White
Formula: C16H22Cl2N2O Appearance: Powder
Other Names: U47700 Molar Mass: 329.27 G·mol−1
CAS: 82657-23-6

 

1. Quick details

 

Means Of Transport: Air Package: In Foil Bag Or Customized
Product Name: U48800 Production Capacity: 500kg/month
Cas No:

82657-23-6

 

Min.Order: Negotiation
Skype:

 live:sales02_1697
 

Appearance: Powder
Port:

Hongkong

Application: Chemical Research

 

2. Definitions

U-48800 is an opioid analgesic drug developed by a team at Upjohn in the 1970s that acts as a selective agonist of the µ-opioid receptor with a Kd value of 5.3 nM compared to 910 nM for the κ-opioid receptor and has around 7.5 x the potency of morphine in animal models.

 

3. character

U-48800 is a structural isomer of the earlier and the result of a great deal of work elucidating the quantitative structure–activity relationship of the scaffold.

 

Upjohn looked for the key moieties which gave the greatest activity[8] and posted over a dozen patents on related compounds, each optimizing one moiety] until they discovered that U-48800 was the most active.

 

U-48800 became the lead compound of selective kappa-opioid receptor ligands such as (containing a single methylene spacer difference) and U-69,593, which share very similar structures. Although not used medically, the selective kappa ligands are used in research.

 

4. Pharmacology
U-48800 is selective for the µ-opioid receptor, with various sources claiming 7.5x the potency of morphine.

Opioids exert their effects by binding to and activating the μ-opioid receptor. This occurs because opioids structurally mimic endogenous endorphins which are naturally found within the body and also work upon the μ-opioid receptor set.

 

The way in which opioids structurally mimic these natural endorphins results in their euphoria, pain relief and anxiolytic effects. This is because endorphins are responsible for reducing pain, causing sleepiness, and feelings of pleasure. They can be released in response to pain, strenuous exercise, orgasm, or general excitement.

 

U-48800 may also be an agonist for the kappa-opioid receptor system. As a result of this, it has become the lead compound of selective kappa-opioid receptor ligands such as U-50488 and U-69,593, which share very similar structures. Its structure led to other chemists experimenting with it to see if rigid analogues would retain activity.  Although not used medically, the selective kappa ligands are used in research

 

 

5. Company Introduction

Dongmao Biotechnology Co., Limited specializes in exporting high quality Research chemical, medical intermediate, Pharmaceutical chemicals and so on.

 

Our products are produced on the basis of best technical team, advanced equipment, high qualified management which meets the requirements of security and environmental protection.

 

We earned customers' trust and created a good reputation during these years. we are committed to providing excellent quality products and the perfect service to friends all over the world.

 

We will provide the most comprehensive products and service to you!

We are looking forward to your cooperation.

 

6. Pictures

U48800 white powder Research Chemical Intermediates CAS No 82657-23-6

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